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Related Experiment Videos

Olfactory dysfunction in multiple sclerosis: relation to longitudinal changes in plaque numbers in central olfactory

R L Doty1, C Li, L J Mannon

  • 1Smell & Taste Center, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA.

Neurology
|September 17, 1999
PubMed
Summary

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Multiple Sclerosis (MS) patients with more brain plaques showed lower smell identification test scores. This suggests olfactory loss in MS is linked to changes in central olfactory brain regions.

Area of Science:

  • Neuroimmunology
  • Olfactory Neuroscience

Background:

  • Olfactory dysfunction is a common symptom in Multiple Sclerosis (MS).
  • The underlying mechanisms linking MS pathology to olfactory loss require further elucidation.

Purpose of the Study:

  • To investigate the longitudinal relationship between brain lesion load and olfactory function in MS patients.

Main Methods:

  • Five MS patients underwent serial assessments over 18-20 months.
  • Evaluated were University of Pennsylvania Smell Identification Test (UPSIT) scores and MRI-determined plaque counts in the inferior frontal and temporal lobes.

Main Results:

  • A significant inverse correlation was observed between plaque numbers and UPSIT scores.
  • Increased plaque burden longitudinally corresponded with decreased olfactory identification ability.

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Conclusions:

  • Findings support the hypothesis that olfactory loss in MS is associated with fluctuations in demyelinating lesions within central olfactory brain regions.
  • This highlights the potential for olfactory testing as a biomarker for MS disease activity.