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Related Experiment Videos

W/O/W Multiple Emulsions Submitted to a Linear Shear Flow: Correlation between Fragmentation and Release.

Muguet1, Seiller, Barratt

  • 1Laboratoire de Dermopharmacologie et Cosmétologie, Laboratoire de Physique Pharmaceutique, Laboratoire de Pharmacie Galénique et de Biopharmacie URA CNRS 1218, Centre d'études Pharmaceutiques, 5 rue J. B. Clément, Châtenay-Malabry, 92296, France

Journal of Colloid and Interface Science
|September 18, 1999
PubMed
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This study validates Taylor's theory for multiple emulsions under shear, finding good agreement but revealing complex fragmentation mechanisms that can limit electrolyte release.

Area of Science:

  • Colloid and Surface Science
  • Rheology
  • Materials Science

Background:

  • Multiple emulsions are complex systems with applications in various industries.
  • Understanding droplet fragmentation and content release under stress is crucial for formulation stability and efficacy.
  • Taylor's theoretical framework provides a model for predicting droplet behavior.

Purpose of the Study:

  • To apply Taylor's theory to multiple emulsions subjected to shear stress.
  • To investigate the correlation between droplet fragmentation and the release of entrapped substances.
  • To elucidate the mechanisms governing droplet breakup and their impact on release efficiency.

Main Methods:

  • Experimental application of Taylor's theoretical framework.
  • Shear stress application to various multiple emulsion systems.

Related Experiment Videos

  • Analysis of droplet fragmentation patterns.
  • Quantification of entrapped electrolyte release.

    • Main Results:

    • Experimental results showed good agreement with Taylor's theoretical predictions.
    • A strong correlation was established between emulsion fragmentation and electrolyte release.
    • Droplet breakup mechanisms were found to be complex.
    • Complete release of entrapped electrolyte was not always achieved.

    Conclusions:

    • Taylor's theory is applicable to multiple emulsions under shear.
    • Complex breakup phenomena, like partial leakage and microglobule expulsion, can hinder complete substance release.
    • Formulation design must account for these complex release mechanisms.