Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgA nephropathy. From molecules to men.

Y Tomino1

  • 1Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Contributions to Nephrology
|September 18, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient classification and outcome prediction in IgA nephropathy.

Computers in biology and medicine·2015
Same author

Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice.

Clinical and experimental immunology·2015
Same author

Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin.

Diabetologia·2012
Same author

Asymmetric dimethylarginine: a novel cardiovascular risk factor in end-stage renal disease.

The Journal of international medical research·2012
Same author

Negative regulation of inflammatory responses by immunoglobulin A receptor (FcαRI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis.

Clinical and experimental immunology·2011
Same author

Significance of glomerular activation of the alternative pathway and lectin pathway in lupus nephritis.

Lupus·2011

This review details 25 years of research on Immunoglobulin A (IgA) nephropathy, a common cause of kidney failure. It explores the disease

Area of Science:

  • Nephrology
  • Immunology
  • Glomerulonephritis

Background:

  • Immunoglobulin A (IgA) nephropathy is a primary immune-complex-mediated glomerulonephritis.
  • Characterized by IgA1 and C3 deposition in the glomerular mesangium, leading to proliferative changes and matrix expansion.
  • It is a leading cause of chronic glomerulonephritis and end-stage renal disease.

Purpose of the Study:

  • To review the author's extensive research on the pathogenesis and treatment of IgA nephropathy.
  • To present the latest findings on IgA nephropathy mechanisms and therapeutic strategies.
  • To serve as a comprehensive resource for clinicians managing IgA nephropathy.

Main Methods:

  • Longitudinal study of IgA nephropathy over 25 years.
  • Development of animal models for IgA nephropathy.

Related Experiment Videos

  • Investigation of various therapeutic approaches, including tonsillectomy, anticoagulants, and immunosuppressants.

    • Main Results:

    • Significant contributions to understanding the development and progression mechanisms of IgA nephropathy.
    • Exploration of novel treatment strategies for patients with IgA nephropathy.
    • Establishment of valuable animal models for further research.

    Conclusions:

    • Despite extensive research, the pathogenesis of IgA nephropathy remains incompletely understood, necessitating further investigation.
    • Current treatments are largely supportive, highlighting the need for targeted therapies.
    • The reviewed work provides a foundation for future advancements in IgA nephropathy management.