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Updated: Jul 29, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
How many visits by health professionals are needed to make a difference in low birthweight? A dose-response study of
1Toronto Public Health. dellen@region.waterloo.ca
Insights
The Toronto Healthiest Babies Possible (HBP) program effectively reduces low birthweight (LBW) in mothers facing risks like smoking and adolescence. Optimal results were seen with 9-11 program home visits.
Area of Science:
- Maternal and Child Health
- Public Health Interventions
- Perinatal Epidemiology
Background:
- Established risk factors for low birthweight (LBW) include smoking, nutrition, and adolescence.
- The mediating role of program interventions and necessary intervention levels for LBW reduction remain less understood.
Purpose of the Study:
- To investigate the Toronto Healthiest Babies Possible (HBP) program's effectiveness in mediating the impact of smoking, adolescence, prepregnancy underweight, and weight fluctuations on LBW.
- To determine the dose-response relationship between the number of HBP home visits and LBW outcomes.
Main Methods:
- Retrospective analysis of program data linking maternal risk factors and intervention exposure (number of home visits) to birthweight outcomes.
- Statistical modeling to assess the HBP program's mediating effect and identify the optimal number of home visits for LBW reduction.
Main Results:
- The HBP program demonstrates a positive impact, mediating the effects of smoking, adolescence, and prepregnancy underweight on LBW.
- A dose-response relationship was observed, with 9-11 home visits identified as the most effective intervention level for reducing LBW.
Conclusions:
- The Healthiest Babies Possible (HBP) program is a valuable strategy for mitigating risks associated with LBW.
- The findings suggest a benchmark for intervention intensity, indicating 9-11 home visits as a critical threshold for significant LBW reduction.
Abstract:
The association of risk factors such as smoking, nutrition and adolescence with low birthweight has been well documented. What is less known is the extent to which certain program interventions can mediate the impact of these risks on low birthweight and the level of intervention necessary to have an impact. This study had two objectives: (a) to explore the role of the Toronto Healthiest Babies Possible (HBP) program as a mediator of the impact of smoking, adolescence, prepregnancy underweight and erratic weight gain/initial weight loss on LBW, and (b) to determine the dose-response relationship between the number of home visits and LBW. Study results suggest that the HBP strategy is making a difference for clients with the aforementioned three risk factors, and that the most effective intervention "dose" to reduce low birthweight is 9-11 visits. This type of study may serve as a benchmark in the evaluation of other similar programs.
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