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Related Experiment Videos

Inflammation does not decrease intraluminal pH in chronic inflammatory bowel disease.

K Ewe1, S Schwartz, S Petersen

  • 1Medizinische Klinik und Poliklinik Johannes Gutenberg University Mainz, Germany.

Digestive Diseases and Sciences
|September 18, 1999
PubMed
Summary
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Intestinal inflammation from Crohn's disease and ulcerative colitis does not lower gastrointestinal pH. This finding supports the use of pH-dependent drug delivery systems for treating these inflammatory bowel diseases.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Clinical Medicine

Background:

  • Intestinal inflammation is a hallmark of inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis.
  • The intraluminal pH environment within the gastrointestinal tract can influence drug absorption and efficacy.
  • It is hypothesized that inflammation may alter the physiological pH levels in the gut.

Purpose of the Study:

  • To investigate the intraluminal pH profiles in patients with active Crohn's disease and ulcerative colitis.
  • To determine if intestinal inflammation affects gastrointestinal pH.
  • To assess the implications of intraluminal pH findings for pH-controlled drug delivery systems.

Main Methods:

  • Gastrointestinal pH was measured using a pH-sensitive telemetering capsule in 15 patients with active Crohn's disease, 5 patients with ulcerative colitis, and 15 healthy controls.

Related Experiment Videos

  • A metal sphere attached to the capsule allowed for precise localization within the gastrointestinal tract.
  • pH measurements were taken across different segments of the gastrointestinal tract, including inflamed areas.

    • Main Results:

    • Physiological pH patterns were maintained throughout the gastrointestinal tract, even in inflamed segments.
    • Median terminal ileum pH in Crohn's disease patients was 7.5 (vs. 7.7 in controls).
    • Median rectal pH in ulcerative colitis patients was 7.8 (vs. 7.2 in controls).

    Conclusions:

    • Intraluminal pH is not significantly decreased by inflammatory changes in Crohn's disease or ulcerative colitis.
    • These findings suggest that eudragit-coated, pH-controlled-release formulations of mesalazine can dissolve effectively in inflamed intestinal areas.
    • The study supports the feasibility of using pH-dependent drug delivery for treating IBD patients.