Related Experiment Videos
Illusory self-motion and motion sickness: a model for brain-gut interactions and nausea
1Section of Gastroenterology and Hepatology, The Pennsylvania State University, The Milton S. Hershey Medical Center, Hershey 17033, USA.
Digestive Diseases and Sciences
|September 18, 1999
Summary
Illusory self-motion causes nausea by altering gastric electrical activity and increasing vasopressin. This study links tachygastrias and elevated vasopressin to motion sickness intensity, suggesting genetic factors influence susceptibility.
Area of Science:
- Neuroscience
- Gastroenterology
- Physiology
Background:
- Motion sickness is a model for studying nausea.
- Illusory self-motion (vection) can induce nausea, gastric dysrhythmias, and stress hormone release.
Purpose of the Study:
- To investigate the relationship between vection-induced nausea and electrogastrograms (EGGs).
- To examine the correlation between nausea intensity, gastric dysrhythmias, and vasopressin levels.
Main Methods:
- Electrogastrography (EGG) was used to measure gastric myoelectrical activity.
- Subjects experienced illusory self-motion using a rotating drum.
- Plasma vasopressin levels and nausea intensity were quantified.
Main Results:
- Vection-induced nausea was preceded by shifts in EGG to tachygastrias.
- The power in the tachygastria range correlated with nausea intensity.
- Higher nausea intensity and vasopressin levels were observed in Asian subjects compared to Caucasian subjects.
Conclusions:
- Illusory self-motion provokes significant gastric electrical and hormonal changes.
- Gastric dysrhythmias and vasopressin release may play a role in nausea and cyclic vomiting syndrome.
- Genetic factors may contribute to susceptibility to vection-induced motion sickness.
Keywords:
Non-programmatic