Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serotonin receptor physiology: relation to emesis.

W L Hasler1

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA.

Digestive Diseases and Sciences
|September 18, 1999
PubMed
Summary

Serotonin (5-HT) receptor research reveals new antiemetic applications. Targeting specific 5-HT receptor subtypes offers promising treatments for various forms of nausea and vomiting.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country.

Alimentary pharmacology & therapeutics·2017
Same author

Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis.

Neurogastroenterology and motility·2017
Same author

Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.

Neurogastroenterology and motility·2017
Same author

Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing.

Neurogastroenterology and motility·2016
Same author

Nausea and vomiting in gastroparesis: similarities and differences in idiopathic and diabetic gastroparesis.

Neurogastroenterology and motility·2016
Same author

Baseline features and differences in 48 week clinical outcomes in patients with gastroparesis and type 1 vs type 2 diabetes.

Neurogastroenterology and motility·2016

Area of Science:

  • Pharmacology
  • Neuroscience
  • Gastroenterology

Background:

  • Serotonin (5-HT) receptors are crucial in the central nervous system and gut, playing a role in emesis.
  • Multiple 5-HT receptor subtypes have been identified through pharmacological and molecular methods.

Purpose of the Study:

  • To review the current understanding and therapeutic potential of various serotonin receptor subtypes in managing nausea and vomiting.
  • To explore the efficacy of different 5-HT receptor ligands in treating diverse emetic conditions.

Main Methods:

  • Review of existing literature on serotonin receptor pharmacology and clinical applications.
  • Analysis of data from studies investigating 5-HT receptor agonists and antagonists in models of emesis.

Main Results:

  • 5-HT3 antagonists are effective in chemotherapy-induced, radiation-induced, and postoperative nausea and vomiting, as well as hyperemesis gravidarum and nausea in AIDS patients.
  • 5-HT4 agonists show prokinetic effects in gastroparesis and functional dyspepsia.
  • 5-HT1D, 5-HT1A, and 5-HT2A/5-HT2C receptor agonists demonstrate antiemetic properties in specific conditions like migraine and cyclic vomiting syndrome.

Conclusions:

  • Serotonin receptor modulation is a key strategy for treating emesis.
  • Ongoing research into 5-HT receptor ligands promises expanded therapeutic options for nausea and vomiting disorders.

Related Experiment Videos