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High IL-18 (interferon-gamma inducing factor) concentration in a purine nucleoside phosphorylase deficient patient
T Yamamoto1, Y Moriwaki, K Matsui
1Third Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.
Archives of Disease in Childhood
|September 22, 1999
Abstract:
The plasma concentration of IL-18 (interferon-gamma inducing factor) was severely increased in a 3 year old boy with purine nucleoside phosphorylase (PNP) deficiency. The presence and activity of IL-18 were confirmed by immunoblotting and bioassay, respectively. These results suggest that IL-18 may be abundantly produced and secreted into plasma by PNP deficient macrophages in PNP deficiency.