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Novel findings about 24,25-dihydroxyvitamin D: an active metabolite?
1Genetics Unit, Shriners Hospital for Children, Montréal, Québec, Canada. rst-arnaud@shriners.mcgill.ca
Current Opinion in Nephrology and Hypertension
|September 24, 1999
Abstract:
The physiological role of 24,25-dihydroxyvitamin D remains controversial. Recent results suggest that 24,25-dihydroxyvitamin D is essential for fracture healing, and binding sites for 24,25-dihydroxyvitamin D have been identified in fracture callus tissue. Mice deficient in the 25-hydroxyvitamin D-24-hydroxylase enzyme provide novel genetic tools in which to study the role of 24,25-dihydroxyvitamin D in bone development and fracture repair.