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Cardiovascular dysfunction due to shift work.

K Murata1, E Yano, T Shinozaki

  • 1Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.

Journal of Occupational and Environmental Medicine
|September 24, 1999
PubMed
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Shift work significantly prolongs the heart-rate corrected QT interval (QTc), a marker linked to cardiac death risk. This study suggests shift work may increase cardiovascular mortality due to QTc prolongation.

Area of Science:

  • Occupational Health
  • Cardiology
  • Physiology

Background:

  • Shift work is prevalent globally, affecting millions of workers.
  • Previous studies have suggested a link between shift work and cardiovascular disease, but the underlying mechanisms remain unclear.

Purpose of the Study:

  • To investigate the impact of shift work on cardiovascular functions.
  • To determine if shift work is associated with specific electrocardiographic changes, particularly the heart-rate corrected QT interval (QTc).

Main Methods:

  • Collected electrocardiographic, biochemical, and physical data from 237 shift workers and 115 day workers.
  • Utilized multiple regression analysis to assess the relationship between work schedule (shift vs. day) and QTc interval.
  • Defined prolonged QTc as >= 440 ms1/2.

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Main Results:

  • Shift workers exhibited a significantly longer QTc interval compared to day workers.
  • Shift work was independently and significantly related to QTc prolongation in all workers.
  • The adjusted odds ratio for shift work being associated with a prolonged QTc was 8.15.

Conclusions:

  • Shift work is associated with a prolonged heart-rate corrected QT interval (QTc).
  • QTc prolongation is a potential mechanism linking shift work to an increased risk of cardiovascular mortality.