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Updated: Sep 30, 2026
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Histopathology and molecular genetics of renal tumors toward unification of a classification system
N R Zambrano1, I A Lubensky, M J Merino
1Urologic Oncology Branch, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1502, USA.
Purpose:
We characterize the genetic abnormalities associated with pathological subtypes of renal tumors, which may help diagnosis or prognostication.
Materials And Methods:
A comprehensive literature review of genetic abnormalities associated with different renal tumor subtypes was performed.
Results:
Studies of sporadic and hereditary forms suggest that abnormalities in the von Hippel-Lindau and met genes are the earliest changes in conventional (clear cell) and papillary basophilic renal cancers, respectively. Renal oncocytoma and chromophobe carcinoma have common genetic abnormalities, suggesting a relationship. A similar finding has been observed between papillary adenoma and papillary basophilic renal cancer.
Conclusions:
These findings suggest that molecular diagnostic testing will help determine histopathological diagnosis, identify tumor types with similar genetic abnormalities suggesting a common origin and indicate potential prognostic markers for future study.
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