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Serum sickness induced by bupropion.

J C Yolles1, W A Armenta, A O Alao

  • 1Inpatient Psychiatry, SUNY Health Science Center, Syracuse, NY 13210, USA. yollesj@vax.cs.hscsyr.edu

The Annals of Pharmacotherapy
|September 24, 1999
PubMed
Summary

This case study reports a patient who developed serum sickness, an adverse drug reaction, after taking bupropion for depression. Symptoms resolved after discontinuing the medication, suggesting bupropion as the cause.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Background:

  • Bupropion is an antidepressant medication used for depression and smoking cessation.
  • Serum sickness is a hypersensitivity reaction typically occurring after exposure to foreign proteins or certain medications.

Observation:

  • A 45-year-old male patient developed delirium, fever, myalgia, arthralgia, and rash within 24 hours of starting bupropion for depression with psychosis.
  • Symptoms improved within two weeks after discontinuing bupropion.

Findings:

  • The patient's presentation and the temporal relationship with bupropion initiation, coupled with the exclusion of other causes, led to a diagnosis of serum sickness.
  • This case represents the first reported instance of serum sickness induced by bupropion.

Implications:

  • This finding highlights a previously unrecognized adverse drug reaction associated with bupropion.
  • Clinicians should consider serum sickness in patients presenting with compatible symptoms after bupropion initiation.
  • Further investigation may be warranted to understand the mechanism and incidence of bupropion-induced serum sickness.

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