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Losartan-induced angioedema.

¹Cooperative Pharmacy Program, University of Texas Austin, USA. JRivera@utep.edu

The Annals of Pharmacotherapy

|September 24, 1999

Summary

This case study highlights a rare instance of angioedema, a serious allergic reaction, linked to the medication losartan. The findings suggest losartan can cause late-onset angioedema that may recur.

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Area of Science:

Pharmacology
Clinical Medicine
Adverse Drug Reactions

Background:

Angiotensin II receptor antagonists (ARBs) like losartan are commonly prescribed for hypertension.
Angioedema is a known, albeit rare, side effect associated with Angiotensin-Converting Enzyme (ACE) inhibitors.
The incidence and characteristics of angioedema specifically related to losartan are not well-established.

Observation:

A 45-year-old male patient developed two episodes of angioedema within 10 hours of initiating losartan/hydrochlorothiazide.
The patient had a history of hypertension and gout, was on allopurinol and colchicine, and had normal renal function.
Notably, the patient had no prior exposure to ACE inhibitors, and the angioedema reaction was of late onset and recurred.

Findings:

This case suggests that losartan, an ARB, can induce angioedema.
The observed angioedema was characterized by late onset and recurrence.
The reaction occurred in a patient with normal renal function, distinguishing it from some previously reported cases.

Implications:

Clinicians should consider losartan as a potential cause of late-onset angioedema, even in patients with normal renal function.
The potential for recurrence of losartan-induced angioedema warrants careful patient monitoring.
Further research is needed to determine the precise incidence and risk factors for angioedema associated with losartan and other ARBs.

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