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Related Experiment Videos

Propafenone disposition during continuous venovenous hemofiltration.

W Seto1, A E Trope, R M Gow

  • 1Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada. wseto@interlog.com

The Annals of Pharmacotherapy
|September 24, 1999
PubMed
Summary

Continuous venovenous hemofiltration (CVVH) did not significantly remove propafenone in a critically ill child. Propafenone clearance was unaffected by renal or liver dysfunction.

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Diagnosis of postoperative arrhythmias following paediatric cardiac surgery.

Anaesthesia and intensive care·2009

Area of Science:

  • Pharmacokinetics
  • Critical Care Medicine
  • Nephrology

Background:

  • Propafenone is an antiarrhythmic medication used to treat tachyarrhythmias.
  • Continuous venovenous hemofiltration (CVVH) is a renal replacement therapy used in critically ill patients with acute kidney injury.
  • The use of CVVH in critically ill pediatric patients requiring propafenone necessitates an understanding of its removal by this modality.

Observation:

  • A pediatric patient developed junctional ectopic tachycardia post-cardiac surgery, requiring propafenone therapy.
  • The patient also developed acute renal failure, necessitating initiation of CVVH.
  • Serum and ultrafiltrate concentrations of propafenone and its metabolite were measured during CVVH.

Findings:

  • Propafenone was not significantly removed by continuous venovenous hemofiltration.

Related Experiment Videos

  • CVVH clearance of propafenone was minimal.
  • Total propafenone clearance was not impacted by the patient's renal or hepatic function impairment.

    • Implications:

    • CVVH is unlikely to be an effective method for propafenone removal in critically ill pediatric patients.
    • Dosing adjustments for propafenone may not be necessary in pediatric patients undergoing CVVH, even with renal or liver dysfunction.
    • Further studies are warranted to confirm these findings in a larger pediatric population.