Effects of dietary selenium on biochemical composition of rat testis

Treatment of rats with selenium (6 and 8 ppm in diet) for 6 and 9 weeks resulted in decrease in testicular protein, phospholipid content and LDH activity and an increase in the lipid, cholesterol content and activity of ACP and ALP. These alterations have been discussed in relation to interference of selenium in various metabolic processes of testis. It seems that selenium affects the oxido-reductase activity of glutathione and resulting in oxidative damage to testis.