Related Experiment Video
Updated: Aug 4, 2026
09:15
Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
Published on: October 10, 2017
Onychomycosis in diabetes. Management considerations
D A Albreski1, A K Gupta, E G Gross
1Podiatry Section, Veterans Affairs Connecticut Healthcare Systems, Newington, USA.
Postgraduate Medicine
|September 24, 1999
Summary
Onychomycosis, a fungal nail infection, is increasingly common worldwide. Recent advances in antifungal treatments offer new hope for managing this serious condition, which impacts quality of life and can lead to severe health complications.
Area of Science:
- Medical Mycology
- Dermatology
- Infectious Diseases
Background:
- Onychomycosis (fungal nail infection) prevalence is rising globally, affecting 2-13% of the population.
- Historically underestimated, onychomycosis significantly impairs patient quality of life.
- Diagnosis and management of onychomycosis are challenging across medical disciplines.
Purpose of the Study:
- To review recent advancements in medical mycology and oral antifungal agents for onychomycosis.
- To highlight the clinical significance of treating onychomycosis, especially in patients with comorbidities.
Main Methods:
- Literature review of recent developments in medical mycology.
- Analysis of epidemiological data on onychomycosis incidence and prevalence.
- Discussion of clinical management strategies and treatment outcomes.
Main Results:
- New oral antifungal agents show promise in onychomycosis treatment.
- Rising global incidence underscores the need for effective management strategies.
- Untreated onychomycosis can lead to severe, potentially life-threatening complications.
Conclusions:
- Renewed interest in onychomycosis management due to therapeutic advancements.
- Effective treatment is crucial for improving patient well-being and preventing serious health risks.
- Onychomycosis requires comprehensive diagnostic and therapeutic approaches.
Related Concept Videos
01:22Diabetes Mellitus: Overview and Type I Subtype
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
01:15Diabetes: Symptoms, Diagnosis, and Complications
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
01:15Diabetes: Management and Pharmacotherapy
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
01:19Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
01:22Complications of Diabetes Mellitus
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...