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Dengue epidemic in the State of Rio Grande do Norte, Brazil, in 1997
R V Cunha1, H G Schatzmayr, M P Miagostovich
1Disciplina de Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Rio de Janeiro, Brazil. rivaldoc@alanet.com.br
Abstract:
During 1997 a large dengue epidemic occurred in Rio Grande do Norte, a State in north-east Brazil. The co-circulation of dengue virus type 1 and dengue virus type 2 was demonstrated by virus isolation in Aedes albopictus clone C6/36 cell-line and by reverse transcriptase-polymerase chain reaction (RT-PCR). IgM capture enzyme-linked immunosorbent assay confirmed 52.3% of the 8105 studied cases and dengue antigen was demonstrated by immunohistochemical reaction on hepatocytes from 2 out of 5 fatal cases studied. Individual risk factors for development of dengue haemorrhagic fever/dengue shock syndrome, such as hypertension, diabetes mellitus and bronchial asthma, are discussed.