[Development of a vaccine for treatment of urinary tract infections]

Receiving uroinfections are predominantly treated with antibiotics and chemotherapeutics. An effective alternative treatment can be immunotherapy with inactivated bacteria. The authors have focused on the development of polybacterial vaccine with both specific and nonspecific immunostimulatory activity. The vaccine contains killed bacteria which most frequently occur as an etiological agent in urinary tract infections. Determining for the selection of particular strains for the vaccine preparation were their immunostimulatory properties evaluated after intraperitoneal application of killed cells to mice. The results were evaluated according to weight gain of liver and spleen and verified by histological examination of these organs. The final form of the vaccine URVAKOL contains immunogenically most active strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa and Enterococcus faecalis, representing specific effective part of the preparation, adjuvant activity is provided by Propionibacterium acnes. (Tab. 1, Fig. 2, Ref. 27.)