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The anti-carcinogenic role of lycopene, abundantly present in tomato
1Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Calcutta, India.
Abstract:
Among the many carotenoids present in nature, lycopene has been of special interest and has received attention in recent times due to its suggestive association in reducing risk for cancer at many sites including breast, prostate and pancreas. Several studies have attempted to determine the bioactive levels of this carotenoid in human tissues and the influence of plant food and cancer on carotenoid levels. Experimental studies have also implicated the protective role of lycopene during carcinogenesis. These observations should justify further exploration and evaluation of the biological function of lycopene alone or in combination with other chemical compounds present in tomato fruit for their use in cancer prevention.
Insights
Lycopene, a carotenoid found in tomatoes, shows promise in reducing the risk of various cancers. Further research into its biological functions could lead to new cancer prevention strategies.
Area of Science:
- Nutritional science
- Oncology
- Carotenoid research
Background:
- Lycopene is a prominent carotenoid with potential health benefits.
- Previous studies suggest lycopene's association with reduced cancer risk at multiple sites.
- Dietary factors, including plant foods, influence carotenoid levels in human tissues.
Purpose of the Study:
- To explore the role of lycopene in cancer prevention.
- To evaluate the biological functions of lycopene, individually and in combination with other tomato compounds.
Main Methods:
- Review of existing literature on lycopene and cancer.
- Analysis of studies investigating bioactive levels of carotenoids in human tissues.
- Examination of experimental data on lycopene's role in carcinogenesis.
Main Results:
- Lycopene is linked to a reduced risk of breast, prostate, and pancreatic cancers.
- Experimental studies indicate a protective effect of lycopene against carcinogenesis.
- Variations in carotenoid levels are observed based on diet and cancer status.
Conclusions:
- Lycopene's potential in cancer prevention warrants further investigation.
- Understanding lycopene's biological mechanisms can inform cancer prevention strategies.
- Tomato-derived compounds, including lycopene, may play a role in future cancer prevention therapies.