Related Experiment Video
Updated: Jan 23, 2026
08:22
Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria
Published on: May 16, 2025
552
Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells
T Komiya1, M Kyohkon, S Ohwaki
1Faculty of Bioresources, Mie University, Tsu-city, Mie 514-0001, Japan.
International Journal of Molecular Medicine
|September 24, 1999
Summary
Phytol, derived from Lolium multiflorum, inhibits human lymphoid leukemia Molt 4B cell growth by inducing apoptosis. This programmed cell death involves morphological changes and DNA fragmentation, demonstrating phytol
Area of Science:
- Molecular Biology
- Cell Biology
- Phytochemistry
Background:
- Human lymphoid leukemia Molt 4B cells are a model for studying leukemia progression.
- Phytol is a natural compound with potential biological activities.
- Understanding novel therapeutic agents for leukemia is crucial.
Purpose of the Study:
- To investigate the effect of phytol isolated from Lolium multiflorum on Molt 4B cells.
- To determine if phytol induces growth inhibition and/or programmed cell death (apoptosis) in these cells.
Main Methods:
- Phytol was isolated from Lolium multiflorum and identified using Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy.
- Molt 4B cells were exposed to varying concentrations and times of phytol treatment.
- Morphological changes, including the formation of apoptotic bodies, and DNA fragmentation were analyzed.
Main Results:
- Phytol exposure resulted in significant growth inhibition of Molt 4B cells.
- Morphological analysis revealed the characteristic features of apoptosis, such as apoptotic bodies.
- Concentration- and time-dependent DNA fragmentation into oligonucleosomal-sized fragments was observed, confirming apoptosis induction.
Conclusions:
- Phytol isolated from Lolium multiflorum effectively inhibits the growth of human lymphoid leukemia Molt 4B cells.
- The mechanism of growth inhibition is mediated through the induction of apoptosis.
- Phytol demonstrates potential as a therapeutic agent for lymphoid leukemia.
More Related Videos
Related Concept Videos
01:18Lymphoid Cells and Tissues
3.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.0K
01:30Overview of Cell Death
9.6K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.6K
01:18Autophagic Cell Death
4.4K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.4K
01:13Induced Pluripotent Stem Cells
27.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
01:06Induced Pluripotent Stem Cells
5.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
5.4K
01:15Secondary Lymphoid Organs
9.0K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
9.0K