Related Experiment Video
Updated: Aug 16, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
[Child with swelling of eyelids and face; not always due to allergy]
Y Thomasse1, H van Unen, J J van Collenburg
1Isala Klinieken, afd. Kindergeneeskunde, Zwolle.
Abstract:
Three boys aged 3.5, 4.5 and 2.5 years, developed puffy eyelids and a swollen face. Initially, their symptoms were attributed to allergy. However, careful history taking, physical examination and laboratory studies (urinalysis and serum albumin) showed that the presenting symptoms were the first signs of nephrotic syndrome. Specific therapy induced rapid remission of the nephrotic syndrome in all patients. In children with puffy eyelids and a swollen face, nephrotic syndrome should be considered in the differential diagnosis. Appropriate laboratory studies (urinalysis) are indicated to reach the correct diagnosis so that appropriate therapy can be initiated.
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