Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta-cell ion channels: keys to endodermal excitability.

L H Philipson1

  • 1Department of Medicine, University of Chicago, IL 60637, USA. l-philipson@uchicago.edu

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|September 24, 1999
PubMed
Summary

Delayed rectifier (Kv) K+ channels regulate pancreatic beta-cell electrical excitability and insulin secretion. Kv1 channels appear less significant, with focus shifting to Kv2 and Kv3 channels in beta-cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pain Control, Glucose Control, and Quality of Life in Patients With Chronic Pancreatitis After Total Pancreatectomy With Islet Autotransplantation: A Preliminary Report.

Transplantation proceedings·2017
Same author

External Validation of the Newly Developed BETA-2 Scoring System for Pancreatic Islet Graft Function Assessment.

Transplantation proceedings·2017
Same author

Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls.

Diabetic medicine : a journal of the British Diabetic Association·2016
Same author

Resting beta-cells - A functional reserve?

Diabetes & metabolism·2016
Same author

Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis.

Islets·2013
Same author

Genome wide association studies for diabetes: perspective on results and challenges.

Pediatric diabetes·2013

Area of Science:

  • Endocrinology
  • Neuroscience
  • Ion Channel Physiology

Background:

  • Pancreatic beta-cells, though not neurons, are specialized excitable cells.
  • Electrical excitability in beta-cells is regulated by multiple ion channels.
  • Delayed rectifier (Kv) K+ channels are crucial for repolarization and insulin secretion.

Purpose of the Study:

  • To define the specific roles of Kv channel genes in regulating insulin secretion.
  • To investigate the contribution of different Kv channel families (Kv1, Kv2, Kv3) in pancreatic beta-cells.

Main Methods:

  • Analysis of Kv channel gene expression (mRNA detection).
  • Functional studies involving inhibition of Kv channel activity.
  • Investigation of beta-cell calcium oscillations in response to glucose.

Main Results:

  • Kv channels play a significant role in regulating glucose-stimulated beta-cell calcium oscillations.
  • Kv1 family mRNA is present in islets, but Kv1 channels are unlikely to be major regulators in beta-cells.
  • Kv2 and Kv3 channels are emerging as key players in beta-cell function.

Conclusions:

  • Kv channels are critical for beta-cell electrical activity and insulin release.
  • The focus is shifting from Kv1 to Kv2 and Kv3 channels for understanding beta-cell regulation.
  • Further research on Kv2 and Kv3 channels is needed to elucidate their precise roles.

Related Experiment Videos