Advances in non-peptide glucagon receptor antagonists

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Published on: February 26, 2019

P Madsen1, C L Brand, J J Holst

  • 1Departments of Medicinal Chemistry, Novo Nordisk A/S, Novo Nordisk Park, Maaloev, DK-2760 Maaloev, Denmark. pem@novo.dk

Current Pharmaceutical Design
|September 25, 1999
PubMed

Insights

Glucagon receptor antagonism shows promise for treating Type 2 diabetes. Animal studies indicate glucagon

Area of Science:

  • Endocrinology
  • Pharmacology
  • Metabolic Diseases

Background:

  • Glucagon plays a significant role in glucose metabolism and is implicated in Type 2 diabetes.
  • Understanding glucagon's diabetogenic effects is crucial for developing new therapeutic strategies.

Purpose of the Study:

  • To review glucagon receptor antagonism as a potential treatment for Type 2 diabetes.
  • To summarize progress in the development of non-peptide glucagon receptor antagonists.

Main Methods:

  • Analysis of studies using glucagon antibodies in animal models to assess glucagon's role.
  • Review of published literature on various classes of non-peptide glucagon receptor antagonists.

Main Results:

  • Selective glucagon deficiency in animal models indicates glucagon's importance in maintaining euglycemia.
  • Glucagon antagonism is suggested as a potentially beneficial and safe therapeutic approach for Type 2 diabetes.
  • Several classes of non-peptide glucagon receptor antagonists have been identified, including quinoxalines and pyridyl-diarylpyrroles.

Conclusions:

  • Glucagon receptor antagonism represents a promising therapeutic avenue for Type 2 diabetes.
  • Further research into non-peptide antagonists is warranted to advance treatment options.

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