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Related Experiment Videos

Signet-ring cell formation in cutaneous neoplasms.

B C Bastian1, H Kutzner, Ts Yen

  • 1Department of Dermatology, University of Würzburg, Germany.

Journal of the American Academy of Dermatology
|September 25, 1999
PubMed
Summary

Signet-ring cells in skin tumors are not always adenocarcinoma. These cells form from vacuoles, not secretory products, appearing in various skin cancers and mimicking other cell types.

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Area of Science:

  • Dermatopathology
  • Oncology
  • Cell Biology

Background:

  • Signet-ring cells, characterized by intracytoplasmic substance accumulation displacing the nucleus, are typically associated with adenocarcinoma in epithelial neoplasms.
  • Their presence in dermatopathology is rare, prompting investigation into their formation and significance.

Purpose of the Study:

  • To survey rare occurrences of signet-ring cells in dermatopathology specimens.
  • To investigate the mechanisms behind signet-ring cell formation in cutaneous neoplasms.

Main Methods:

  • Analysis of 23 cutaneous tumors exhibiting a significant signet-ring cell population.
  • Utilized immunohistochemistry and electron microscopy for detailed cellular examination.

Main Results:

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  • Signet-ring cells were identified in diverse cutaneous neoplasms, including squamous cell carcinoma, basal cell carcinoma, melanoma, and metastatic adenocarcinoma.
  • Vacuoles in non-adenocarcinoma signet-ring cells were negative for Periodic Acid Schiff (PAS), PAS-digest, and colloidal iron stains.
  • Immunohistochemistry for keratins and vimentin was negative in vacuoles; electron microscopy revealed empty spaces.

Conclusions:

  • The signet-ring appearance in most cutaneous neoplasms likely results from coalescing intracytoplasmic vacuoles, not secretory product accumulation.
  • Signet-ring cell formation is not specific to cellular lineage and can occur across various cutaneous neoplasms.
  • This phenomenon is analogous to other cellular alterations like rhabdoid, granular, clear, spindle, balloon cells, and oncocytes.