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[Primary pleural non-Hodgkin's lymphoma without chronic pyothorax]
M Kanno1, S Nakamura, C Uotani
1Department of Internal Medicine, NTT Kanazawa Hospital.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|September 25, 1999
Summary
This study presents a rare case of primary pleural non-Hodgkin's lymphoma without chronic pyothorax. Human herpes virus 8 (HHV-8) DNA was detected, and the lymphoma relapsed after initial remission.
Area of Science:
- Oncology
- Pathology
- Virology
Background:
- Primary pleural malignant lymphoma typically arises secondary to chronic pyothorax.
- Non-Hodgkin's lymphoma (NHL) of the pleura is an uncommon malignancy.
- Understanding rare presentations of pleural lymphoma is crucial for diagnosis and treatment.
Observation:
- A 63-year-old woman presented with massive right pleural effusion and a pleural mass on imaging.
- Initial investigations for infection (Mycobacterium) and lymphoma cells in effusion were negative.
- Human herpes virus 8 (HHV-8) DNA was detected in peripheral blood and pleural fluid.
Findings:
- A diagnosis of diffuse large B-cell non-Hodgkin's lymphoma (stage IE) was confirmed via pleural needle biopsy.
- HHV-8 DNA was detected in peripheral blood and pleural effusion, but not in the biopsied pleural mass.
- The patient achieved complete remission but experienced relapse approximately 8 months later.
Implications:
- This case highlights a rare presentation of primary pleural NHL not associated with chronic pyothorax or Kaposi's sarcoma.
- The detection of HHV-8 DNA suggests a potential, albeit uncommon, etiological role in this specific presentation.
- Further research into the role of viral infections in rare pleural malignancies is warranted.