[Analysis of cell-to-cell interaction in immune system through cellular adhesion molecules]

Bio defense mechanisms are the result of the complicated interaction between leukocytes and other tissues, which is based on the close association of 3D (three-dimensional) cell surface structure with cellular adhesion molecules using ImmunoSEM to analyze 3D microdistribution of cellular adhesion molecules, this review discusses the stiff adhesion of lymphocytes to HEV endothelial cells, the establishment of microvilli as a pathway for leukocyte migration, and the formation of ultrastructures showing an antigen-presenting sign via the unique 3D microdistribution of adhesion molecules. In addition it is shown that a combination of health immuno-liposome method and energy filter TEM is an effective means of investigating cell-to-cell interaction in in vivo and molecular interaction among various kinds of cellular adhesion molecules.