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Antibiotic residues in milk samples obtained from cows after treatment for papillomatous digital dermatitis
J S Britt1, M C Carson, J D von Bredow
1Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706-1102, USA.
Objective:
To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline.
Design:
Randomized controlled clinical trial.
Animals:
28 lactating Holstein cows with PDD.
Procedure:
Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high-performance liquid chromatography and a commercially available tetracycline screening test.
Results:
None of the cows in either treatment group had violative residues of oxytetracycline in milk samples.
Conclusions And Clinical Relevance:
Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk.
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