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Substituted amylose as a matrix for sustained drug release
C Chebli1, I Moussa, S Buczkowski
1Faculté de Pharmacie, Université de Montréal, Québec, Canada.
Pharmaceutical Research
|September 25, 1999
Summary
Substituted amylose (SA) polymers offer a versatile platform for creating sustained drug release systems. Tailoring SA polymer properties through chemical modification enhances their utility in controlled drug delivery matrix tablets.
Area of Science:
- Polymer Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Amylose derivatives represent a significant class of polymers with established applications.
- Many amylose derivatives are recognized for their potential in drug sustained-release systems.
Purpose of the Study:
- To synthesize various substituted amylose (SA) polymers.
- To investigate the impact of polymer structure and substitution degree on drug release.
Main Methods:
- SA polymers were synthesized via a one-step reaction in a basic medium.
- Substituents (A-R) were introduced, where (A) is a reactive functional group and (R) is an organic radical.
- Matrix tablets were prepared by direct compression for drug release studies.
Main Results:
- The synthesis of diverse SA polymers was achieved.
- Varying substituents (A and/or R) and degrees of substitution (n) influenced drug release kinetics.
- Drug release from matrix tablets demonstrated sustained release profiles.
Conclusions:
- Substituted amylose polymers are valuable excipients for pharmaceutical formulations.
- SA polymers facilitate the development of effective controlled drug release tablets.