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Related Experiment Videos

Surface photograft polymerization on segmented polyurethane using the iniferter technique.

H J Lee1, T Matsuda

  • 1Department of Bioengineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan.

Journal of Biomedical Materials Research
|September 25, 1999
PubMed
Summary

Surface modification of segmented polyurethane (SPU) films using dithiocarbamate initiation resulted in highly wettable surfaces. Grafted poly(ethylene glycol) methacrylate (PEGMA) surfaces showed minimal platelet adhesion, indicating improved biocompatibility.

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Area of Science:

  • Polymer Chemistry
  • Surface Science
  • Biomaterials

Background:

  • Segmented polyurethane (SPU) is widely used in biomedical applications but can elicit adverse biological responses.
  • Surface modification is crucial for enhancing the biocompatibility of SPU materials.
  • Developing advanced surface functionalization techniques is essential for tailoring material properties.

Purpose of the Study:

  • To develop a novel method for surface graft polymerization on SPU films.
  • To investigate the effect of surface modification on wettability and chemical composition.
  • To evaluate the blood compatibility of the modified SPU surfaces.

Main Methods:

  • Chloromethylation and dithiocarbamation of SPU films.
  • Surface-initiated graft polymerization of poly(ethylene glycol) methacrylate (PEGMA) and N, N-dimethyl-acryl amide (DMAAm) using UV irradiation.

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  • Surface characterization using X-ray photoelectron spectroscopy (XPS).
  • Assessment of platelet adhesion using platelet-rich plasma.

    • Main Results:

    • The dithiocarbamate-initiated surface graft polymerization successfully altered SPU surface properties.
    • The modified surfaces exhibited significantly enhanced wettability.
    • XPS analysis confirmed successful grafting and changes in surface composition.
    • Poly(PEGMA)-grafted SPU surfaces demonstrated minimal platelet adhesion, suggesting excellent hemocompatibility.

    Conclusions:

    • Dithiocarbamate-mediated UV-induced graft polymerization is an effective strategy for modifying SPU surfaces.
    • The resulting poly(PEGMA) and poly(DMAAm) grafted surfaces show improved wettability and hemocompatibility.
    • This surface modification technique holds promise for developing advanced biomaterials with reduced thrombogenicity.