Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A conserved blueprint for the eye?

J E Treisman1

  • 1Skirball Institute for Biomolecular Medicine and Department of Cell Biology, NYU Medical Center, 540 First Avenue, New York, New York 10016, USA. treisman@saturn.med.nyu.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|September 25, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell-autonomous and -nonautonomous functions of LAR in R7 photoreceptor axon targeting.

Neuron·2001
Same author

Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein.

Current biology : CB·2001
Same author

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

Cell·2001
Same author

An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development.

Developmental biology·2001
Same author

The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc.

Development (Cambridge, England)·2001
Same author

Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes.

Genes & development·2000

Researchers identified key transcription factors in Drosophila eye development. Homologous proteins in vertebrates suggest an ancient regulatory network for visual organ formation across species.

Area of Science:

  • Developmental Biology
  • Genetics
  • Evolutionary Biology

Background:

  • Organismal eye structures and development are diverse, despite a common function in visual perception.
  • Early eye development involves the specification of a cell field that will form the eye.

Purpose of the Study:

  • To identify transcription factors crucial for the initial stages of eye development in Drosophila.
  • To explore the evolutionary conservation and adaptation of regulatory networks in visual organ formation.

Main Methods:

  • Investigated early eye development in Drosophila.
  • Identified putative transcription factors involved in cell field specification.
  • Compared identified factors with homologous proteins in vertebrate eye development.

Related Experiment Videos

Main Results:

  • A hierarchical set of transcription factors was identified for Drosophila eye field specification.
  • Cross-regulation among these factors appears to amplify cell fate decisions.
  • Homologous proteins in vertebrates suggest an ancient conserved regulatory network.

Conclusions:

  • The regulatory network for eye development likely originated in a common ancestor.
  • This network has been adapted for visual organ formation in diverse species.
  • Further research on upstream/downstream genes will clarify developmental field establishment and pathway divergence.