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Updated: Aug 9, 2026

Quantitative In vitro Assay to Measure Neutrophil Adhesion to Activated Primary Human Microvascular Endothelial Cells under Static Conditions
Published on: August 23, 2013
[Role of adhesion molecules in the pathogenesis of COPD]
1Department of Pulmonary Medicine, Jichi Medical School.
Abstract:
Recruitment and activation of inflammatory cells such as neutrophils, lymphocytes, and macrophages are important events in the pathogenesis of chronic obstructive pulmonary disease (COPD). Adhesion molecules play an central role in these processes. Several clinical investigations have demonstrated that the expression of ICAM-1 on the bronchial epithelium and E-selectin on bronchial mucosal vessels was increased in the patients with COPD. These findings suggested that adhesion molecules are involved in the pathogenesis of COPD.
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