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Related Experiment Videos

Factors affecting success in an embryo cryopreservation programme.

S K Loh1, N K Leong

  • 1Dept of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. kkivf@kkh.com.sg

Annals of the Academy of Medicine, Singapore
|September 25, 1999
PubMed
Summary

Embryo cryopreservation success rates improved yearly. Natural cycle endometrial preparation yielded the highest pregnancy rates, particularly when embryo transfer occurred between days 14-16.

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • Cryobiology

Background:

  • Embryo cryopreservation is integral to assisted conception.
  • Clinical factors influencing frozen embryo transfer (FET) success require analysis.
  • Optimizing FET protocols can enhance overall program efficacy.

Purpose of the Study:

  • To analyze clinical factors affecting FET success.
  • To identify predictors of successful embryo cryopreservation and transfer.
  • To refine assisted conception program practices based on empirical data.

Main Methods:

  • Retrospective analysis of 212 FET cycles from 1994-1996.
  • Statistical evaluation using Student's t-test, Fisher's exact test, and chi-square test.
  • Investigation of factors: endometrial preparation, embryo number, woman's age, endometrial thickness.

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Main Results:

  • Clinical pregnancy rate increased yearly, reaching 12.3% per transfer in 1996.
  • Natural cycle preparation (17.7% pregnancy rate) outperformed hormone-replacement cycles.
  • Optimal outcomes observed with transfer on days 14-16 (33% pregnancy rate), younger maternal age, ≥2 embryos transferred, and endometrial thickness ≥11 mm.

Conclusions:

  • Natural cycle preparation is superior for ovulatory women with regular cycles.
  • Hormonal preparation protocols require further refinement for non-ovulatory cycles.
  • Embryo cryopreservation significantly improves overall assisted conception success rates.