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Related Experiment Videos

Organotin compounds and their interactions with microorganisms.

J S White1, J M Tobin, J J Cooney

  • 1School of Biotechnology, Dublin City University, Ireland.

Canadian Journal of Microbiology
|September 25, 1999
PubMed
Summary

Organotin compounds, like tributyltin (TBT), exhibit toxicity to microorganisms by interacting with cell membranes and intracellular enzymes. Environmental factors and microbial resistance mechanisms influence these interactions and the environmental fate of organotins.

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Area of Science:

  • Environmental Chemistry
  • Microbiology
  • Toxicology

Background:

  • Organotin compounds are widespread environmental contaminants.
  • Toxicity generally increases with the number and length of organic groups attached to tin.
  • Organotins are lipophilic and considered membrane-active, with potential intracellular targets.

Purpose of the Study:

  • To investigate the mechanisms and sites of organotin toxicity in microorganisms.
  • To explore the influence of environmental factors on microorganism-organotin interactions.
  • To understand microbial resistance and biotransformation of organotins.

Main Methods:

  • Biosorption studies on fungi, cyanobacteria, and microalgae.
  • Enzyme activity assays on bacteria exposed to tributyltin (TBT).

Related Experiment Videos

  • Analysis of environmental factors (pH, salinity) affecting organotin speciation and reactivity.

    • Main Results:

    • Cell surface binding was observed in fungi, cyanobacteria, and microalgae.
    • TBT interacted with cytosolic enzymes in some bacteria.
    • Environmental factors like pH and salinity influence organotin reactivity and microbial resistance.
    • Tin-resistant microorganisms possess plasmid or chromosomally mediated resistance, potentially involving efflux systems.
    • Biotransformation pathways like debutylation and methylation were observed.

    Conclusions:

    • Organotin toxicity involves both cell surface interactions and intracellular effects.
    • Environmental conditions modulate organotin toxicity and microbial resistance.
    • Microbial biotransformation impacts the environmental fate and toxicity of organotins.