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Rhodesian trypanosomiasis in a splenectomized patient.

M A Malesker1, D Boken, T A Ruma

  • 1Alegent Health Immanuel Medical Center, Department of Pharmacy Practice, Creighton University, Omaha, Nebraska 68178, USA.

The American Journal of Tropical Medicine and Hygiene
|September 25, 1999
PubMed
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A splenectomized man developed severe trypanosomiasis, a parasitic infection, with central nervous system effects. This case suggests spleen removal may not alter disease onset or severity in humans infected with Trypanosoma brucei rhodesiense.

Area of Science:

  • Medical Parasitology
  • Infectious Diseases
  • Immunology

Background:

  • The role of the spleen in Trypanosoma brucei rhodesiense infections remains poorly understood.
  • Existing research primarily focuses on animal models, leaving human responses unclear.

Observation:

  • A 41-year-old male, who had undergone splenectomy, presented with severe Trypanosoma brucei rhodesiense infection after an East African safari.
  • The patient exhibited central nervous system involvement.
  • Symptoms, laboratory findings, and disease progression were consistent with previously documented cases.

Findings:

  • This case represents the first reported instance of a splenectomized individual developing severe human African trypanosomiasis.
  • The absence of a spleen did not appear to influence the onset or overall severity of the illness.

Related Experiment Videos

  • Treatment with suramin and melarsoprol was successful.

    • Implications:

    • The findings suggest that asplenia may not significantly impact the clinical presentation or progression of Trypanosoma brucei rhodesiense infections in humans.
    • Further research is warranted to elucidate the spleen's precise role in trypanosomiasis.
    • This case contributes to understanding host-parasite interactions in immunocompromised individuals.