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2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists
M G Russell1, M S Beer, J A Stanton
1Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK. michael_russell@merck.com
Bioorganic & Medicinal Chemistry Letters
|September 25, 1999
Abstract:
The conformational restriction of a (benzylamino)methyl substituted pyrrolidine to form 2,7-diazabicyclo[3.3.0]octanes has led to a series of compounds with high affinity at the h5-HT1D receptor as well as dramatically increased concentrations in the hepatic portal vein following oral administration.