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Facile synthesis of N-protected gamma and delta-amino-beta-keto-esters
1Department of Chemistry, Hunter College / CUNY, New York City, NY 10021, USA.
Bioorganic & Medicinal Chemistry Letters
|September 25, 1999
Abstract:
The C-acylation of Meldrum's acid by protected amino acids, using isopropenyl chloroformate (IPCF) as the condensing agent, is described. The process is used to synthesize gamma and delta-amino-beta-keto-esters.