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Toxic shock syndrome toxin-1 (TSST-1) antibody levels in burned children

C Childs1, V Edwards Jones, M Dawson

  • 1MRC Trauma Group, Regional Paediatric Burns Unit, Booth Hall Children's Hospital, Manchester, UK. cchilds@man.ac.uk

Burns : Journal of the International Society for Burn Injuries
|September 25, 1999
PubMed

Insights

Young children with burns face toxic shock-like illness risk. Many young burn patients have antibodies to toxic-shock syndrome toxin-1 (TSST-1), suggesting potential susceptibility.

Area of Science:

  • Pediatric Burn Care
  • Immunology
  • Infectious Diseases

Background:

  • Young children with burns are susceptible to toxic shock-like illness within 2-3 days post-injury.
  • Staphylococcal exotoxin, toxic-shock syndrome toxin-1 (TSST-1), is a key factor in this illness.
  • Low or absent anti-TSST-1 antibodies may indicate increased susceptibility.

Purpose of the Study:

  • To measure anti-TSST-1 antibody levels in young children admitted to a pediatric burns unit.
  • To assess the prevalence of anti-TSST-1 antibodies in this vulnerable population.

Main Methods:

  • Measurement of IgG antibodies against TSST-1.
  • Study included 38 pediatric patients aged 0.04-4.0 years admitted to a burns unit.

Main Results:

  • 50% of the children studied possessed IgG antibodies to TSST-1 upon admission.
  • The observed prevalence of anti-TSST-1 antibodies was higher than anticipated in this cohort.

Conclusions:

  • A significant proportion of young children with burns have pre-existing antibodies to TSST-1.
  • This finding warrants further investigation into the role of TSST-1 and antibody levels in pediatric burn-related toxic shock-like illness.

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