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Risk factors and outcomes for atherothrombotic disease in French patients: the RIVAGE study. RIsque VAsculaire Group
1Institut des Vaisseaux et du Sang, Service d'Angio-Hématologie Clinique et Biologieque, Hôpital Lariboisère, Paris, France. elisabeth.mazoyer@lrb.ap-hop-paris.fr
Thrombosis Research
|September 25, 1999
Summary
Plasma fibrinogen levels predict recurrent cardiovascular events in patients with atherosclerotic disease. Higher fibrinogen correlates with more severe and fatal events, guiding risk assessment and treatment strategies.
Area of Science:
- Cardiovascular Medicine
- Epidemiology
- Clinical Research
Background:
- Atherosclerotic disease encompasses peripheral arterial disease, ischemic heart disease, and cerebrovascular disease.
- Understanding the course and predictors of recurrent events is crucial for patient management.
- French patients represent a key demographic for studying cardiovascular disease progression.
Purpose of the Study:
- To describe the natural history of atherosclerotic disease in French patients.
- To identify clinical and laboratory factors predicting recurrent cardiovascular events.
- To analyze predictors of fatal cardiovascular outcomes.
Main Methods:
- Prospective observational study design.
- Inclusion of 2416 patients with diagnosed peripheral arterial disease, ischemic heart disease, or cerebrovascular disease.
- 18-month follow-up period with event recording and laboratory testing in a subset.
Main Results:
- 15.7% of patients experienced recurrent cardiovascular events within 18 months.
- Recurrent events often occurred in the same vascular bed as the initial event.
- Plasma fibrinogen level was the sole independent predictor of all recurrent cardiovascular events and was strongly correlated with fatal events.
Conclusions:
- Plasma fibrinogen is a significant independent predictor of recurrent cardiovascular events, including fatal outcomes.
- Age and smoking status are associated with event incidence, while event location is often consistent.
- Findings highlight the importance of fibrinogen monitoring in atherosclerotic disease management.