Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rhabdomyosarcoma--working out the pathways.

G Merlino1, L J Helman

  • 1Molecular Genetics Section, Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA.

Oncogene
|September 28, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insomnia and daytime sleepiness predict 20-year mortality in older male adults: data from a population-based study.

Sleep medicine·2020
Same author

miR-30e* is an independent subtype-specific prognostic marker in breast cancer.

British journal of cancer·2015
Same author

Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma.

Oncogene·2013
Same author

Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth.

Oncogene·2013
Same author

Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2012
Same author

Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L).

Oncogene·2010

Rhabdomyosarcoma, a childhood cancer, arises from disrupted skeletal muscle cell development. Understanding its molecular pathways is key to improving treatment for high-risk and metastatic cases.

Area of Science:

  • Oncology
  • Developmental Biology
  • Genetics

Background:

  • Rhabdomyosarcomas are childhood cancers linked to abnormal skeletal muscle progenitor cell growth.
  • In vitro studies of myogenic cells have improved understanding of rhabdomyosarcoma pathogenesis.
  • Growth factors and MyoD family proteins regulate the balance between cell proliferation and differentiation.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying rhabdomyosarcoma development.
  • To identify key regulatory factors and genetic alterations in rhabdomyosarcoma.
  • To explore novel therapeutic strategies for rhabdomyosarcoma.

Main Methods:

  • Analysis of normal and malignant myogenic cells in vitro.
  • Identification of diagnostic cytogenetic markers.

Related Experiment Videos

  • Investigation of regulatory mechanisms of myogenesis.
  • Study of cell cycle factors and their mutations.

    • Main Results:

    • Disruption of the proliferation-differentiation balance is crucial in rhabdomyosarcoma.
    • Mutations in cell cycle regulatory factors subvert myogenesis.
    • In vitro studies have identified key molecular players.

    Conclusions:

    • Rhabdomyosarcoma pathogenesis involves dysregulated myogenesis.
    • Targeting cell cycle factors and molecular pathways may offer therapeutic opportunities.
    • Genetically engineered mouse models are expected to advance research.