Related Experiment Video
Updated: Aug 10, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
[Graft vs host disease and cytomegalovirus: looking for common pathogenetic link based on discussion about viral
Abstract:
Acute graft-versus-host reaction (GVH) is the most severe complication of allogeneic bone marrow transplantation. It has been shown that higher morbidity and heavier course refers to cytomegalovirus (CMV) seropositive recipients who obtain bone marrow from seronegative donors. In this work hypothetical model linking pathogenesis of acute GVH to CMV infection is discussed. CMV superantigen is postulated to trigger the immunological reaction. Antigen presenting cells of the host expose it on their surface which results in activation of allogeneic T lymphocytes.
Related Concept Videos
Cell-mediated Immune Responses
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cytomegalovirus Disease
Hepatitis
Viral Hepatitis I: Introduction

