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Related Experiment Videos

Moxidectin in cattle: correlation between plasma and target tissues disposition.

A Lifschitz1, G Virkel, F Imperiale

  • 1Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Tandil, Argentina.

Journal of Veterinary Pharmacology and Therapeutics
|September 28, 1999
PubMed
Summary

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Parasitology·2023

Moxidectin (MXD) distributes widely in cattle tissues and fluids, persisting for up to 58 days. Higher concentrations were found in gastrointestinal mucosa and skin compared to plasma, influencing antiparasitic activity.

Area of Science:

  • Veterinary Pharmacology
  • Pharmacokinetics
  • Parasitology

Background:

  • The efficacy of antiparasitic drugs depends on drug concentration and duration of exposure.
  • Understanding drug distribution in target tissues is crucial for optimizing treatment protocols.

Purpose of the Study:

  • To evaluate the disposition kinetics of moxidectin (MXD) in cattle plasma and various tissues.
  • To correlate drug concentrations with the persistence of antiparasitic activity.

Main Methods:

  • Subcutaneous injection of moxidectin (200 µg/kg) in Holstein calves.
  • Collection of plasma, tissue (abomasal, intestinal mucosa, lung, skin), and fluid (bile, feces) samples over 68 days.
  • Quantification of moxidectin using high-performance liquid chromatography (HPLC) with fluorescence detection.

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Main Results:

  • Moxidectin was detected in all analyzed tissues and fluids for up to 58 days post-administration.
  • Higher moxidectin concentrations were observed in abomasal/intestinal mucosa and skin compared to plasma.
  • Significant excretion of moxidectin occurred via bile and feces.

Conclusions:

  • Moxidectin exhibits extensive tissue distribution and prolonged persistence in cattle.
  • Concentration differences in tissues suggest targeted activity against endo- and ectoparasites.
  • These pharmacokinetic findings provide insights into moxidectin's antiparasitic efficacy duration.