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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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[Structural equation analysis and modeling of upper limb WMSDs and their adverse ergonomic factors].

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[Study on the relationship between occupational exposure characteristics and musculoskeletal disorders in 29 industries or workforce groups in China].

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Related Experiment Video

Updated: Jun 18, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Cigarette smoke aggravates experimental colitis in rats.

F Galeazzi1, P A Blennerhassett, B Qiu

  • 1Intestinal Diseases Research Programme, Health Sciences Centre, McMaster University, Hamilton, Ontario, Canada.

Gastroenterology
|September 29, 1999
PubMed
Summary

Cigarette smoking worsens experimental colitis in rats. This effect is reversed by hexamethonium, indicating a neural pathway is involved in smoking

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Last Updated: Jun 18, 2026

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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research
  • Toxicology

Background:

  • Tobacco smoking's impact on intestinal inflammation is complex, with protective effects in ulcerative colitis but detrimental effects in Crohn's disease.
  • Nicotine is thought to mediate smoking's beneficial effects, but mechanisms for its adverse effects remain unclear.
  • Investigating smoking's adverse mechanisms in experimental colitis is crucial for understanding its role in gastrointestinal diseases.

Purpose of the Study:

  • To examine the effect of cigarette smoking on experimental colitis in rats.
  • To investigate the underlying neural mechanisms of smoking-induced aggravation of colitis.

Main Methods:

  • Rats were exposed to daily cigarette smoke or sham conditions.
  • Colitis was induced using dinitrobenzenesulfonic acid (DNBS) after 2 weeks of smoke exposure.
  • Hexamethonium, a ganglionic blocker, was administered to assess its effect on smoke-induced colitis.

Main Results:

  • Cigarette smoke exposure significantly increased macroscopic and histological damage in rats with colitis.
  • Myeloperoxidase activity was elevated in smoke-exposed rats, indicating increased inflammation.
  • Hexamethonium treatment prior to smoking reversed the detrimental effects of smoke on colitis parameters.

Conclusions:

  • Cigarette smoking aggravates dinitrobenzenesulfonic acid-induced colitis in rats.
  • The neural blocker hexamethonium reversed the pro-inflammatory effects of smoking.
  • These findings suggest that a neural pathway mediates the adverse effects of cigarette smoking on experimental colitis.