Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Autoimmune hepatitis and/or hepatitis C].

J Simonović1, Lj Dokić, N Svirtlih

  • 1Institute of Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade.

Srpski Arhiv Za Celokupno Lekarstvo
|September 29, 1999
PubMed
Summary

Hepatitis C virus (HCV) infection is linked to autoimmune phenomena in 22% of patients. This study highlights the importance of examining autoimmune markers for appropriate treatment decisions in patients with HCV.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preparation of male genital organs - a new autopsy technique.

Forensic science, medicine, and pathology·2026
Same author

Self-stigma, religiosity, and perceived social support in people with recent-onset psychosis in the Islamic Republic of Iran: Associations with symptom severity and psychosocial functioning.

The International journal of social psychiatry·2024
Same author

Ambiguous Genitalia and Lissencephaly in A 46,XY Neonate with a Novel Variant of Aristaless Gene.

Acta endocrinologica (Bucharest, Romania : 2005)·2022
Same author

Untreated PKU patients without intellectual disability: <i>SHANK</i> gene family as a candidate modifier.

Molecular genetics and metabolism reports·2021
Same author

Liver anatomy, intrahepatic vascular and biliary branching system of the mole rat (Spalax leucodon).

Folia morphologica·2020
Same author

Rare combination of infective endocarditis in a drug abuser with Henoch-Schoenlein purpura.

Journal of biological regulators and homeostatic agents·2020

Area of Science:

  • Hepatology and Virology
  • Immunology and Autoimmunity

Context:

  • Hepatitis C virus (HCV) is a significant global health concern, causing acute and chronic liver disease.
  • Extrahepatic manifestations and potential links to autoimmune conditions, such as autoimmune hepatitis type 1, are recognized.
  • Accurate diagnosis and therapeutic strategies are crucial, as treatments for HCV and autoimmune hepatitis can conflict.

Purpose:

  • To investigate the prevalence of autoantibodies in patients with Hepatitis C virus infection.
  • To determine the significance of these autoantibodies for diagnosing autoimmune hepatitis type 1.
  • To guide therapeutic decisions in cases of co-existing HCV infection and positive autoantibody findings.

Summary:

  • A study of 49 patients with confirmed HCV infection examined non-specific autoimmune markers (ANA, AMA, ASMA).

Related Experiment Videos

  • Autoantibodies were detected in 22% of patients, with generally insignificant titres.
  • Interferon therapy was administered to five HCV RNA-positive patients without disease progression.

    • Impact:

    • Findings suggest that while HCV infection can be associated with autoimmune phenomena, it may not always indicate autoimmune hepatitis type 1.
    • The study emphasizes the need for careful evaluation of autoimmune markers to guide treatment, differentiating between HCV, autoimmune hepatitis, or co-infection.
    • Results support tailored therapeutic approaches, distinguishing between corticosteroid and interferon therapy based on the predominant condition or co-existence of diseases.