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Treatment of the hypertensive patient with microvascular angina

H Ventura1, P Loyalka, F W Smart

  • 1Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112, USA.

Current Opinion in Cardiology
|September 29, 1999
PubMed

Insights

Syndrome X, also known as microvascular angina, involves heterogeneous diseases. Effective treatments require accurate diagnosis, hypertension control, and further research into nitric oxide and L-arginine roles.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Syndrome X and microvascular angina represent a diverse group of cardiovascular conditions.
  • Existing treatments include ACE inhibitors, beta-blockers, and calcium-channel blockers, with varying success rates.

Purpose of the Study:

  • To highlight the importance of hypertension control and left ventricular hypertrophy regression in managing microvascular angina symptoms.
  • To emphasize the need for further research into the role of nitric oxide and L-arginine in the pathogenesis and treatment of these conditions.

Main Methods:

  • Review of current literature on Syndrome X and microvascular angina treatments.
  • Analysis of the impact of hypertension and left ventricular hypertrophy on symptom presentation.
  • Exploration of the potential therapeutic roles of nitric oxide and L-arginine.

Main Results:

  • Medications like ACE inhibitors, beta-blockers, and calcium-channel blockers show promise in treating microvascular angina.
  • Hypertension management and regression of left ventricular hypertrophy are crucial for symptom control.

Conclusions:

  • Optimal treatment strategies for chest pain in hypertensive patients with normal coronary angiograms depend on precise diagnosis and classification.
  • Further elucidation of nitric oxide and L-arginine pathways is essential for advancing treatment paradigms.

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