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Updated: Jul 14, 2026

A CFSE-based Assay to Study the Migration of Murine Skin Dendritic Cells into Draining Lymph Nodes During Infection with Mycobacterium bovis Bacille Calmette-Guérin

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Published on: October 9, 2016

Mycobacterium ulcerans infection.

T S van der Werf¹, W T van der Graaf, J W Tappero

¹Department of Internal Medicine, Groningen University Hospital, The Netherlands. t.s.van.der.werf@int.azg.nl

Lancet (London, England)

|September 29, 1999

Summary

Buruli ulcer disease, caused by Mycobacterium ulcerans, is a significant health concern in tropical regions, particularly West Africa. Improved treatment, prevention, and research are urgently needed to combat this debilitating mycobacterial infection.

Keywords:

Bacterial And Fungal Diseases Diseases Epidemiology Examinations And Diagnoses Health Infections Laboratory Examinations And Diagnoses Public Health Signs And Symptoms Treatment Vaccines

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Area of Science:

Infectious Diseases
Mycobacteriology
Tropical Medicine

Background:

Buruli ulcer disease, caused by Mycobacterium ulcerans, is the third most common mycobacterial infection in immunocompetent individuals.
The disease is endemic in tropical rainforest regions, with a dramatic increase observed in West Africa over the past decade.
Transmission is suspected via skin abrasions from contact with contaminated water, soil, or vegetation.

Purpose of the Study:

To review the epidemiology, clinical presentation, transmission, and management of Buruli ulcer disease.
To highlight the significant health and economic burden imposed by the disease, especially in underprivileged populations.
To emphasize the need for improved control strategies, including new vaccine development.

Main Methods:

Review of existing literature on Buruli ulcer disease.
Analysis of epidemiological trends and clinical manifestations.
Evaluation of current treatment and prevention strategies.

Main Results:

Buruli ulcer disease presents as painless nodules or large ulcerative lesions, predominantly affecting children.
While lesions heal spontaneously, extensive scarring can lead to severe sequelae like contractures and blindness.
Secondary infections can cause systemic illness and death; current treatment is primarily surgical.

Conclusions:

Buruli ulcer disease poses a substantial health and economic challenge, particularly in West Africa.
BCG vaccination offers mild protection, but new vaccines targeting M. ulcerans toxins are necessary.
Integrated efforts in treatment, prevention, control, and research, supported by international agencies, are crucial for managing Buruli ulcer disease.