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Compliance to multiple interventions in a high risk population.
M B Pettinger1, M A Waclawiw, K B Davis
1Statistics and Epidemiology Research Corporation, Seattle, WA, USA.
Annals of Epidemiology
|September 29, 1999
Summary
Patients with peripheral arterial disease showed good compliance with a complex medication regimen. Further studies are needed to assess this drug combination
Area of Science:
- Cardiovascular Medicine
- Pharmacology
Background:
- Peripheral arterial disease (PAD) presents unique challenges in patient management.
- Treatment strategies for PAD require further investigation, particularly regarding medication adherence.
Purpose of the Study:
- To evaluate medication compliance in patients with PAD.
- To identify factors influencing noncompliance with study medications.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving 468 participants with PAD.
- Medication compliance was assessed via pill counts over a one-year follow-up period.
Main Results:
- Mean overall pill counts ranged from 88-94%, indicating good adherence.
- No significant differences in compliance were observed between active and placebo groups.
- Lower compliance was linked to adverse events and higher rates of side effects in the active niacin group.
Conclusions:
- Patients with PAD can adhere to complex drug regimens.
- The potential of this combination therapy to reduce cardiovascular events and improve quality of life warrants further research.