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Related Experiment Videos

Elevated endogenous cannabinoids in schizophrenia.

F M Leweke1, A Giuffrida, U Wurster

  • 1Department of Clinical Psychiatry and Psychotherapy, Medizinische Hochschule Hannover, Germany.

Neuroreport
|September 29, 1999
PubMed
Summary
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Schizophrenia patients show higher levels of anandamide and palmitylethanolamide in cerebrospinal fluid, suggesting an endocannabinoid system imbalance may contribute to the disorder.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Biochemistry

Background:

  • Cannabinoid receptors and endogenous activators are potential targets for cannabis-derived drugs.
  • Dysfunction in the endocannabinoid system is hypothesized to play a role in schizophrenia.

Purpose of the Study:

  • To investigate alterations in endogenous cannabinoid concentrations in the cerebrospinal fluid (CSF) of individuals with schizophrenia compared to healthy controls.

Main Methods:

  • High-performance liquid chromatography (HPLC) was used to purify endogenous cannabinoids from CSF.
  • Isotope dilution gas-chromatography/mass-spectrometry (GC/MS) quantified cannabinoid levels.
  • 10 patients with schizophrenia and 11 non-schizophrenic controls were analyzed.

Main Results:

Related Experiment Videos

  • Significantly elevated cerebrospinal fluid concentrations of anandamide and palmitylethanolamide were observed in schizophrenic patients (p < 0.05).
  • Levels of 2-arachidonylglycerol were below detection limits in both groups.
  • No significant differences were attributable to gender, age, or medication.

Conclusions:

  • Elevated anandamide and palmitylethanolamide in CSF may indicate an endocannabinoid signaling imbalance in schizophrenia.
  • This imbalance could be a contributing factor to the pathogenesis of schizophrenia.