Lung transplantation: current status and future prospects

Lung transplantation recently marked its 35th anniversary. The period has been marked by 20 years of initially slow progress followed by 15 years of explosive growth and success. In 1997 the number of lung and heart-lung transplants exceeded 1000 in the United States and 1400 worldwide. Current 1-year survival exceeds 75% for most diagnoses. Functional results are excellent and durable with first second expired volume (FEV(1)) improving from 15% to 20% of the predicted normal preoperatively to 75% to 80% of the predicted normal postoperatively in most diagnoses. Problems facing lung transplant programs during the next century include the unavailability of graft lung donors, technical limitations of explanted graft lung preservation, and the prevention and treatment of bronchiolitis obliterans syndrome. Current status and future trends for lung transplantation are reviewed.