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Chitosan microspheres prepared by spray drying.

P He1, S S Davis, L Illum

  • 1Department of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, UK.

International Journal of Pharmaceutics
|September 30, 1999
PubMed
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Chitosan microspheres were developed using spray drying for drug delivery. Crosslinking levels influenced particle size and charge, with drugs showing molecular dispersion and rapid release.

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Chitosan microspheres are promising drug delivery vehicles.
  • Spray drying is an effective method for microsphere preparation.
  • Controlling microsphere properties is crucial for drug release modulation.

Purpose of the Study:

  • To prepare non-crosslinked and crosslinked chitosan microspheres via spray drying.
  • To investigate the influence of crosslinking on microsphere characteristics.
  • To evaluate the drug loading and release behavior of the microspheres.

Main Methods:

  • Chitosan microspheres were prepared using a spray drying technique.
  • Varying concentrations of crosslinking agents (glutaraldehyde, formaldehyde) were employed.

Related Experiment Videos

  • Drug dispersion was analyzed using Differential Scanning Calorimetry (DSC).
  • In vitro drug release studies were conducted using cimetidine, famotidine, and nizatidine.

    • Main Results:

    • Microspheres exhibited good sphericity with a smooth, distorted surface and positive charge.
    • Particle size and zeta potential were significantly affected by the crosslinking level.
    • Lower crosslinking agent concentrations resulted in increased particle size and zeta potential.
    • Drugs were found to be molecularly dispersed within the microspheres as a solid solution.
    • Rapid drug release with a notable burst effect was observed for all model drugs.

    Conclusions:

    • Spray-dried chitosan microspheres can effectively encapsulate H2 antagonist drugs.
    • Crosslinking degree is a key factor in tuning microsphere properties and drug release.
    • The observed rapid release profile suggests potential applications in immediate-release formulations.