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Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

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Surface roughness of cellulose hollow fiber dialysis membranes and platelet adhesion.

N Tsunoda¹, K Kokubo, K Sakai

¹Department of Chemical Engineering, Waseda University, Tokyo, Japan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|September 30, 1999

Summary

Membrane surface roughness significantly impacts hemocompatibility. Smoother membrane surfaces reduce platelet adhesion, leading to improved blood compatibility for medical devices.

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Area of Science:

Biomaterials Science
Hemocompatibility Research
Surface Engineering

Background:

Blood compatibility of membranes is crucial for medical devices.
Both material properties and surface structure influence hemocompatibility.
Flow conditions at the membrane surface play a significant role.

Purpose of the Study:

To investigate the relationship between membrane surface roughness and hemocompatibility.
To evaluate how surface structure affects blood flow characteristics.
To determine the impact of surface roughness on platelet adhesion.

Main Methods:

Utilized five types of membranes with varying surface roughness.
Analyzed inner fiber surfaces using atomic force microscopy (AFM).
Measured platelet adhesion ratios with bovine blood and yield stress using a PMMA glycerol suspension.

Main Results:

Rougher membrane surfaces exhibited higher platelet adhesion and poorer hemocompatibility.
Smoother membrane surfaces demonstrated lower platelet adhesion and better hemocompatibility.
Higher yield stress was observed for rough surfaces, while smoother PEG-grafted surfaces showed lower yield stress.

Conclusions:

Membrane surface roughness is a critical determinant of hemocompatibility.
Surface roughness influences flow conditions, which in turn affect blood compatibility.
Optimizing surface smoothness is key to enhancing hemocompatibility in membrane applications.